SPOUSAL ASSOCIATIONS OF SERUM METABOLOMIC PROFILES BY NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY

Phenotype-based assortative mating is well established in humans, with the potential for further convergence through a shared environment. To assess correlation within infertile couples of physical, social, and behavioural characteristics 155 circulating metabolic measures. Cross sectional study at tertiary medical center 326 undertaking IVF. Serum lipids, lipoprotein subclasses, low-molecular weight metabolites as quantified by NMR spectroscopy (155 measures). Multivariable quantile regression correlations metabolite profiles. Couples exhibited statistical varying strength most including age, height, alcohol consumption, education, smoking status, physical activity, family history ethnicity, coefficients ranging from 0.22 to 0.73. There was no evidence couple associations BMI weight, where were -0.03 (95%CI -0.14, 0.08) 0.01 -0.10, 0.12), respectively. Within spousal measurements all positive but weak modest magnitudes, median coefficient across measures being 0.12 (range 0.37 interquartile range 0.10 0.18). With just four having stronger than 0.3: docosahexaenoic acid (0.37, 95%CI 0.22, 0.52), omega-3 fatty acids (0.32, 0.20, 0.43) histidine 0.23, 0.41) pyruvate 0.43). Infertile exhibit similarities demographic serum measures, supporting initial mating, diet-derived suggesting possible subsequent their individual profile.